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QUICK SPARK: Amgen Stock Eyes Worst Day Since October 2000

  • Amgen’s stock plunged 9.8% after Novartis’ failed Lp(a) trial, shaking confidence in Amgen’s competing therapy.
  • Amgen fell 9.8% to $394.56
  • Novartis ADR shares dropped 14%
  • IBB down 1.8%

Amgen Inc. (NASDAQ: AMGN) fell 9.8% to $394.56 on Tuesday, its steepest one‑day drop since October 2000, after Novartis AG (NYSE: NVS) announced that its investigational lipoprotein(a) therapy, pelacarsen, failed to reduce cardiovascular death, heart attacks or strokes in a Phase 3 trial.

The Novartis setback directly impacted Amgen because Amgen’s olpasiran targets the same lipid (Lp(a)) but with a different mechanism, leading investors to reassess Amgen’s competitive position in the Lp(a) therapeutic space.

Short-term. Short‑term traders should watch Amgen’s price action for a potential rebound as the market digests the Novartis news.

Longer-term. Longer‑term investors should reassess Amgen’s position in the Lp(a) therapeutic arena, considering whether the company’s olpasiran can still compete once Novartis’ failure is factored into the market’s expectations.

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